Deep phenotyping reveals movement phenotypes in mouse neurodevelopmental models.
Ugne KlibaiteMikhail KislinJessica L VerpeutSilke BergelerXiaoting SunJoshua W ShaevitzSamuel S-H WangPublished in: Molecular autism (2022)
Our automated pipeline for deep phenotyping successfully captures model-specific deviations in adaptation and movement as well as differences in the detailed structure of behavioral dynamics. The reported deficits indicate that deep phenotyping constitutes a robust set of ASD symptoms that may be considered for implementation in clinical settings as quantitative diagnosis criteria.