DFMO inhibition of neuroblastoma tumorigenesis.

Divya GandraDavid H MulamaDavid M FoureauKimberly Q McKinneyElizabeth KimKaitlyn SmithJason HawAbhinav NagulapallyGiselle L Saulnier Sholler

Published in: Cancer medicine (2024)

DFMO treatment is cytostatic at physiologically relevant doses and inhibits tumor initiation and progression in mice. This study suggests that DFMO, inhibits neuroblastoma by targeting cellular processes integral to neuroblastoma tumorigenesis at clinically relevant doses.

Keyphrases

combination therapy
skeletal muscle