Myelin heterogeneity for assessing normal appearing white matter myelin damage in multiple sclerosis.

Poljanka JohnsonIrene M VavasourBiljana Jonoska StojkovaShawna AbelLisa Eunyoung LeeCornelia LauleRoger TamDavid K B LiNathalie AckermansAlice J SchabasJillian ChanHelen CrossAna-Luiza SayaoVirginia DevonshireRobert CarruthersAnthony TraboulseeShannon H Kolind

Published in: Journal of neuroimaging : official journal of the American Society of Neuroimaging (2022)

Mean MWF, SD, and MHI provide complementary information when assessing regional and global NAWM abnormalities in MS and associations with clinical outcome measures. Examining all three metrics (mean MWF, SD, and MHI) enables a more detailed interpretation of results, depending on whether regions of interest include areas that are more heterogeneous, earlier in the demyelination process, or uniformly injured.

Keyphrases

white matter
multiple sclerosis
oxidative stress
single cell
mass spectrometry
ms ms
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