Anti-L1 antibody-bound HPV16 pseudovirus is degraded intracellularly via TRIM21/proteasomal pathway.

Meiying LiJianmei HuangYi ZhuZiyi HuangGuonan ZhangJian-Ming Huang

Published in: Virology journal (2022)

Our preliminary results indicate that anti-L1 antibody entered with HPV16 PsV into the cells could mediate degradation of HPV16 PsV by TRIM21-activated proteasomal pathway intracellularly, giving anti-capsid protein L1 antibody a role in host defense of persistent HPV16 infection.

Keyphrases

high grade
cervical cancer screening
induced apoptosis
signaling pathway
oxidative stress
binding protein
endoplasmic reticulum stress