The Role of Pentraxin 3 in Aspergillosis: Reality and Prospects.
Yuening KangYuetian YuLiangjing LuPublished in: Mycobiology (2020)
Pentraxin 3 (PTX3) is a soluble pattern recognition receptor (PRR), which is produced by several kinds of cells, such as neutrophils, dendritic cells, macrophages, and epithelial cells. PTX3 is known to play an important protective effect against Aspergillus. Genetic linkage in gene-targeted mice and human PTX3 plays a non-redundant role in the immune protection against specific pathogens, especially Aspergillus. Recent studies have shown that the polymorphism of PTX3 is associated with increased susceptibility to invasive aspergillosis (IA). In this review, we provide an overview of these studies that underline the potential of PTX3 in diagnosis and therapy of IA.
Keyphrases
- dendritic cells
- genome wide
- endothelial cells
- induced apoptosis
- case control
- cell cycle arrest
- stem cells
- signaling pathway
- cell death
- dna methylation
- cancer therapy
- hepatitis c virus
- climate change
- mesenchymal stem cells
- gram negative
- antimicrobial resistance
- men who have sex with men
- induced pluripotent stem cells
- cell proliferation
- multidrug resistant
- hiv testing
- hiv infected
- wild type
- chemotherapy induced