Age at symptom onset influences cortical thinning distribution and survival in amyotrophic lateral sclerosis.

Pilar M FerraroCorrado CabonaGiuseppe MeoClaudia Rolla-BiglianiLucio CastellanMatteo PardiniMatilde IngleseClaudia CaponnettoLuca Roccatagliata

Published in: Neuroradiology (2021)

More severe frontotemporal CT contributes to shorter survival in older ALS patients. These findings have the potential to unravel the neurobiological mechanisms linking older age at symptom onset to worse prognosis in ALS.

Keyphrases

amyotrophic lateral sclerosis
end stage renal disease
physical activity
newly diagnosed
ejection fraction
patient reported
community dwelling
computed tomography
prognostic factors
free survival
magnetic resonance imaging
early onset
risk assessment
patient reported outcomes
image quality
human health