Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism.

Sheng Zhang Yunkai Zhang Xuewen DuanBo WangZhenzhen Zhan

Published in: Circulation (2024)

Our findings uncover the key role of epigenetic factor NPM1 in impeding postinfarction cardiac repair by remodeling metabolism pattern and impairing the reparative function of cardiac macrophages. NPM1 may serve as a promising prognostic biomarker and a valuable therapeutic target for heart failure after MI.

Keyphrases

acute myeloid leukemia
left ventricular
heart failure
gene expression
dna methylation
adipose tissue
cancer therapy
cardiac resynchronization therapy
long noncoding rna
drug delivery