Modulation of the Itaconate Pathway Attenuates Murine Lupus.

Luz P BlancoEduardo Patino-MartinezShuichiro NakaboMingzeng ZhangHege L PedersenXinghao Wang Carmelo Carmona-RiveraDillon ClaybaughZu-Xi YuEquar DestaMariana J Kaplan

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

These results support targeting immunometabolism as a potentially viable approach in autoimmune disease treatment, with 4-OI displaying beneficial roles attenuating immune dysregulation and organ damage in lupus.

Keyphrases

systemic lupus erythematosus
disease activity
multiple sclerosis
oxidative stress
rheumatoid arthritis
cancer therapy
replacement therapy