Vascular calcification is associated with Wnt-signaling pathway and blood pressure variability in chronic kidney disease rats.
Ruoxi LiaoLiya WangJiameng LiSi SunYuqin XiongYupei LiMei HanHeng JiangMahajan AnilBaihai SuPublished in: Nephrology (Carlton, Vic.) (2019)
We confirmed that CKD rats had enhanced Wnt-signaling in vascular tissue and severer aorta calcification together with increased BPV. Wnt pathway may be a potential target in future VC and BPV management in CKD.
Keyphrases
- chronic kidney disease
- blood pressure
- signaling pathway
- cell proliferation
- stem cells
- pi k akt
- epithelial mesenchymal transition
- pulmonary artery
- current status
- hypertensive patients
- type diabetes
- induced apoptosis
- metabolic syndrome
- adipose tissue
- pulmonary hypertension
- insulin resistance
- risk assessment
- glycemic control