TWEAK Signaling Pathway Blockade Slows Cyst Growth and Disease Progression in Autosomal Dominant Polycystic Kidney Disease.

Adrián Cordido Laura Nuñez-GonzalezJulio M Martinez-MorenoOlaya Lamas-GonzalezLaura Rodriguez-OsorioMaría Vanessa Pérez-GómezDiego Martin-SanchezPatricia OutedaMarco ChiaravalliTerry WatnickAlessandra BolettaCandido DiazAngel CarracedoAna B SanzAlberto Ortiz Arduan Miguel A Garcia-Gonzalez

Published in: Journal of the American Society of Nephrology : JASN (2021)

This study identifies the TWEAK signaling pathway as a new disease mechanism involved in cystogenesis and cystic growth and may lead to a new therapeutic approach in ADPKD.

Keyphrases

polycystic kidney disease
signaling pathway
pi k akt
epithelial mesenchymal transition
induced apoptosis
genome wide
gene expression
cell proliferation
dna methylation