CCNB2 and AURKA overexpression may cause atypical mitosis in Japanese cortisol-producing adrenocortical carcinoma with TP53 somatic variant.

Akira Ikeya Mitsuko NakashimaMiho YamashitaKeisuke KakizawaYuta OkawaHirotomo SaitsuShigekazu SasakiHironobu SasanoTakafumi SudaYutaka Oki

Published in: PloS one (2020)

We believe this is the first report that discusses the relationship between atypical mitotic figures and TP53 somatic variant in ACC. We presumed that overexpression of CCNB2 and AURKA mRNA may cause atypical mitosis in TP53 somatic mutated cases. Because AURKA is highly expressed in atypical mitotic cases, it may be an appropriate indicator for AURKA inhibitors.

Keyphrases

copy number
cell proliferation
cell cycle
transcription factor