Impact of Age and Severe Acute Respiratory Syndrome Coronavirus 2 Breakthrough Infection on Humoral Immune Responses After Three Doses of Coronavirus Disease 2019 mRNA Vaccine.
Francis MwimanziHope R LapointePeter K CheungYurou SangFatima YaseenRebecca KalikaweSneha DatwaniLaura BurnsLandon YoungVictor LeungSiobhan EnnisChanson J BrummeJulio S G MontanerWinnie DongNatalie PrystajeckyChristopher F LoweMari L DeMarcoDaniel T HolmesJanet SimonsMasahiro NiikuraMarc G RomneyZabrina L BrummeMark A BrockmanPublished in: Open forum infectious diseases (2023)
Results underscore the immune benefits of the third COVID-19 mRNA vaccine dose in adults of all ages and identify vaccine-induced Omicron-specific neutralization as a correlate of protective immunity. Systemic antibody responses and functions however, particularly Omicron-specific neutralization, decline rapidly in COVID-19-naive individuals, particularly in older adults, supporting the need for additional booster doses.