Novel Cytotoxic Sesquiterpene Coumarin Ethers and Sulfur-Containing Compounds from the Roots of Ferula turcica .

Six new sesquiterpene coumarin ethers, namely turcicanol A ( 1 ), turcicanol A acetate ( 2 ), turcicanol B ( 3 ), turcica ketone ( 4 ), 11'-dehydrokaratavicinol ( 5 ), and galbanaldehyde ( 6 ), and one new sulfur-containing compound, namely turcicasulphide ( 7 ), along with thirty-two known secondary metabolites were isolated from the root of the endemic species Ferula turcica Akalın, Miski, & Tuncay through a bioassay-guided isolation approach. The structures of the new compounds were elucidated by spectroscopic analysis and comparison with the literature. Cell growth inhibition of colon cancer cell lines (COLO205 and HCT116) and kidney cancer cell lines (UO31 and A498) was used to guide isolation. Seventeen of the compounds showed significant activity against the cell lines.