Dietary therapy of murine primary biliary cholangitis induces hepatocellular steatosis: A cautionary tale.
Weici ZhangTaha Al TekreetiPatrick S C LeungKoichi TsuneyamaHarleen DhillonManuel RojasLuke S HeuerWilliam M RidgwayAftab A AnsariHoward A YoungCharles R MackayMerrill Eric GershwinPublished in: Liver international : official journal of the International Association for the Study of the Liver (2024)
Our data suggest that administration of HAMSP induces both regulatory and effector T cells. Furthermore, HAMSP administration resulted in hepatocellular steatosis. Given the interest in dietary modulation of autoimmunity and because propionate is widely used as a food preservative, these data have significant implications. This study also provides new insights into the immunological and pathological effects of chronic propionate exposure.