Diffusion model comparison identifies distinct tumor sub-regions and tracks treatment response.
Damien J McHughGrazyna Lipowska-BhallaMuhammad BaburYvonne WatsonIsabel PesetHitesh B MistryPenny L Hubbard CristinacceJosephine H NaishJamie HoneychurchKaye J WilliamsJames P B O'ConnorGeoffrey J M ParkerPublished in: Magnetic resonance in medicine (2020)
There is spatial and radiotherapy-related variation in different models' suitability for describing diffusion in tumor tissue, suggesting the presence of different and changing tumor sub-regions. The biological and technical validation of the proposed %MM cancer imaging biomarker suggests it correlates with, but overestimates, the percentage of necrosis.