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Diffusion model comparison identifies distinct tumor sub-regions and tracks treatment response.

Damien J McHughGrazyna Lipowska-BhallaMuhammad BaburYvonne WatsonIsabel PesetHitesh B MistryPenny L Hubbard CristinacceJosephine H NaishJamie HoneychurchKaye J WilliamsJames P B O'ConnorGeoffrey J M Parker
Published in: Magnetic resonance in medicine (2020)
There is spatial and radiotherapy-related variation in different models' suitability for describing diffusion in tumor tissue, suggesting the presence of different and changing tumor sub-regions. The biological and technical validation of the proposed %MM cancer imaging biomarker suggests it correlates with, but overestimates, the percentage of necrosis.
Keyphrases
  • early stage
  • squamous cell carcinoma
  • papillary thyroid
  • genome wide
  • gene expression
  • dna methylation
  • locally advanced
  • mass spectrometry
  • lymph node metastasis
  • rectal cancer
  • squamous cell
  • childhood cancer