Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling.

Jichao SunLina WangHuan BaoSanjay PremiUtpal DasEdwin R ChapmanSubhojit Roy

Published in: Proceedings of the National Academy of Sciences of the United States of America (2019)

The function of α-synuclein (α-syn) has been long debated, and two seemingly divergent views have emerged. In one, α-syn binds to VAMP2, acting as a SNARE chaperone-but with no effect on neurotransmission-while another posits that α-syn attenuates neurotransmitter release by restricting synaptic vesicle mobilization and recycling. Here, we show that α-syn-VAMP2 interactions are necessary for α-syn-induced synaptic attenuation. Our data connect divergent views and suggest a unified model of α-syn function.

Keyphrases

prefrontal cortex
oxidative stress
deep learning
data analysis