Early Treatment and IL1RN Single-Nucleotide Polymorphisms Affect Response to Anakinra in Systemic Juvenile Idiopathic Arthritis.
Manuela PardeoMarianna Nicoletta RossiDenise Pires MarafonEmanuela SaccoClaudia BracagliaChiara PassarelliIvan CaielloGiulia MarucciAntonella InsalacoChiara PerroneAnna TuloneGiusi PrencipeFabrizio De BenedettiPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
Our findings on patients with systemic JIA confirm the important role of early interleukin-1 inhibition and suggest that genetic IL1RN variants predict nonresponse to therapy with anakinra.