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Genotype-phenotype correlation in BRCA1/2 mutation-associated pancreatic cancer.

Maeve Aine Lowery
Published in: British journal of cancer (2019)
Pancreatic cancers occurring in carriers of a pathogenic germline alteration in BRCA1/2 (gBRCA1/2) are assumed to demonstrate homologous recombination repair deficiency (HRD), associated with sensitivity to platinum-based chemotherapy and synthetic lethality with PARP inhibitors (PARPi). However, primary and secondary resistance to these agents occurs even in this highly selected population.
Keyphrases
  • dna repair
  • dna damage
  • breast cancer risk
  • locally advanced
  • replacement therapy
  • oxidative stress