GD2 Target Antigen and CAR T Cells: Does It Take More Than Two to Tango?

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Over the past decade, chimeric antigen receptor T cells have emerged as a breakthrough cancer therapy in selected hematologic malignancies. Translating the success of this therapy to solid tumors is challenging. In this issue, we discuss strategies potentially useful to increase the chimeric antigen receptor T-cell efficacy in this clinical indication. See related article by Fischer-Riepe et al., p. 3564.

Keyphrases

cancer therapy
induced apoptosis
cell cycle arrest
drug delivery
endoplasmic reticulum stress
signaling pathway
bone marrow