Past, Present, and a Glance into the Future of Multiple Myeloma Treatment.
Weam Othman ElbezantiKishore B ChallagundlaSubash C JonnalagaddaTulin Budak-AlpdoganManoj K PandeyPublished in: Pharmaceuticals (Basel, Switzerland) (2023)
Multiple myeloma (MM) is a challenging hematological cancer which typically grows in bone marrow. MM accounts for 10% of hematological malignancies and 1.8% of cancers. The recent treatment strategies have significantly improved progression-free survival for MM patients in the last decade; however, a relapse for most MM patients is inevitable. In this review we discuss current treatment, important pathways for proliferation, survival, immune suppression, and resistance that could be targeted for future treatments.