Microglia proliferation plays distinct roles in acquired epilepsy depending on disease stages.

Martina Di NunzioRossella Di SapiaDiletta SorrentinoValentina KebedeMilica CerovicGiorgia S GullottaMarco BacigaluppiEtienne AudinatNicola MarchiTeresa RavizzaAnnamaria Vezzani

Published in: Epilepsia (2021)

Microglia proliferation during early disease contributes to neurodegeneration, whereas in late chronic disease it contributes to seizures. Timely pharmacological interference with microglia proliferation may offer a potential target for improving disease outcomes.

Keyphrases

signaling pathway
inflammatory response
neuropathic pain
type diabetes
metabolic syndrome
adipose tissue
risk assessment
skeletal muscle
insulin resistance
weight loss
temporal lobe epilepsy