Alamandin and especially melatonin attenuate pulmonary arterial hypertension induced by monocrotalin.

Seyhan Ayik Mehmet Gunata Onural Özhan Azibe Yıldız Nigar Vardi Emre Sonmez Necip Ermis Nilay Ates Ozsoy Ertugrul KilicSamir Abbas Ali NomaAhmet Ulu Seyfullah Taha Inan Haci Ahmet Acet Hakan Parlakpinar

Published in: Fundamental & clinical pharmacology (2024)

ALA, MEL, and ALA + MEL attenuate PAH and protect RV via antiproliferative, anti-remodeling, antihypertrophic, anti-inflammatory, and free radical scavenging (only MEL) capabilities. Overall, MEL produced the best outcomes.

Keyphrases

pulmonary arterial hypertension
pulmonary artery
anti inflammatory
pulmonary hypertension
mycobacterium tuberculosis
adipose tissue
skeletal muscle
insulin resistance