Toxicity of insulin-derived amyloidosis: a case report.

Keiichi IwayaTamotsu ZakoJunta FukunagaKarin Margareta SörgjerdKentaro OgataKoichiro KogureHiroshi KosanoMasayuki NoritakeMizuo MaedaYukio AndoYoshiya KatsuraTerumasa Nagase

Published in: BMC endocrine disorders (2019)

This report showed that toxic insulin-derived amyloidosis can occur. In addition, this report suggested that toxic insulin-derived amyloidosis may cause necrosis in the surrounding tissue. Although the toxic amyloid deposit of insulin-derived amyloidosis was found in only one patient, no structural differences between toxic and non-toxic deposits were seen on histological and immunohistochemical studies.

Keyphrases

type diabetes
glycemic control
multiple myeloma
oxidative stress
case report
adipose tissue
metabolic syndrome