Targeting Dendritic Cell Dysfunction to Circumvent Anti-PD1 Resistance in Head and Neck Cancer.

Shin Saito Michihisa Kono Hoang C B Nguyen Ann Marie Egloff Cameron M Messier Patrick H Lizotte Cloud P Paweletz Douglas R Adkins Ravindra Uppaluri

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

These data highlight the contribution of tumor-infiltrating cDC1 in HNSCC aPD1 response and approaches to enhance cDC1 infiltration and function that may circumvent aPD1 resistance in patients with HNSCC.

Keyphrases

dendritic cells
cell cycle
electronic health record
regulatory t cells
oxidative stress
immune response
cell proliferation
artificial intelligence