Dysfunction of VIPR2 leads to myopia in humans and mice.

Fuxin ZhaoQihang LiWei ChenHe ZhuDengke ZhouPeter Sol ReinachZhenglin YangMingguang HeAnquan XueDeng WuTianzi LiuQian FuChangqing ZengJia QuXiangtian Zhou

Published in: Journal of medical genetics (2020)

Loss of VIPR2 function likely compromises bipolar cell function based on presumed changes in signal transduction due to altered signature electrical wave activity output in these mice. As these effects correspond with increases in form deprivation myopia (FDM), the VIP-VIPR2 signalling pathway axis is a viable novel target to control the development of this condition.

Keyphrases

high fat diet induced
oxidative stress
bipolar disorder
optic nerve
adipose tissue
insulin resistance
metabolic syndrome
skeletal muscle
optical coherence tomography