R2R01: A long-acting single-chain peptide agonist of RXFP1 for renal and cardiovascular diseases.

Bruno PoirierOlivier PasquierXavier ChenedeAlain CorbierPhilippe PrigentAurélien AzamCarine BernardMichel GuillotelFlorence GillotLaurence RivaVeronique BriandRaffaele IngenitoLaurence Gauzy-LazoOlivier DuclosChristophe PhilippoBernard MaillereElisabetta BianchiSergio MallartPhilip JaniakStephane Illiano

Published in: British journal of pharmacology (2024)

R2R01 is a potent RXFP1 agonist with an extended half-life that increases renal blood flow in various settings including normotensive and hypertensive conditions. The preclinical efficacy and safety data supported clinical development of R2R01 as a potential new therapy for renal and cardiovascular diseases.

Keyphrases

blood flow
cardiovascular disease
blood pressure
type diabetes
big data
metabolic syndrome
cell therapy
risk assessment
data analysis