Cerebrolysin alleviates early brain injury after traumatic brain injury by inhibiting neuroinflammation and apoptosis via TLR signaling pathway.
Weihong LuZhonghua ZhuDongliang ShiXiaoyu LiJingzhi LuoXingzhi LiaoPublished in: Acta cirurgica brasileira (2022)
Taken together, the results of this study indicate that CBL can improve neurological outcomes and reduce neuronal death against neuroinflammation and apoptosis via the TLR signaling pathway in mice.
Keyphrases
- cerebral ischemia
- brain injury
- signaling pathway
- subarachnoid hemorrhage
- pi k akt
- cell cycle arrest
- endoplasmic reticulum stress
- inflammatory response
- oxidative stress
- toll like receptor
- blood brain barrier
- induced apoptosis
- immune response
- epithelial mesenchymal transition
- cell death
- spinal cord injury
- lipopolysaccharide induced
- lps induced
- traumatic brain injury
- nuclear factor
- high fat diet induced
- type diabetes
- mouse model
- metabolic syndrome
- cognitive impairment
- white matter
- insulin resistance
- multiple sclerosis