Association between dosing and combination use of medications and outcomes in heart failure with reduced ejection fraction: data from the Swedish Heart Failure Registry.
Domenico D'AmarioDaniele RodolicoGiuseppe M C RosanoUlf DahlströmFilippo CreaLars H LundGianluigi SavaresePublished in: European journal of heart failure (2022)
Heart failure with reduced ejection fraction patients using higher doses of RASi or ARNi and β-blockers had lower risk of cardiovascular death or HF hospitalization. Use of two drug classes at 50%-99% of TD dose was associated with lower risk than one drug class at 100% of TD.
Keyphrases
- heart failure
- acute heart failure
- end stage renal disease
- left ventricular
- ejection fraction
- cardiac resynchronization therapy
- newly diagnosed
- chronic kidney disease
- atrial fibrillation
- prognostic factors
- peritoneal dialysis
- type diabetes
- electronic health record
- machine learning
- big data
- emergency department
- skeletal muscle
- metabolic syndrome
- insulin resistance
- angiotensin converting enzyme
- patient reported outcomes
- artificial intelligence