Cortisol inhibits CSF2 and CSF3 via DNA methylation and inhibits invasion in first-trimester trophoblast cells.

Arianna L SmithElizabeth WitteDevin McGeeJason KnottKavita NarangKaren Racicot

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2017)

In first-trimester trophoblast cells, the physiological glucocorticoid, cortisol, inhibited two cytokines with roles in placental development and decreased trophoblast invasion. Cortisol-associated changes in trophoblast function could increase the risk for immune-mediated abortion or other adverse pregnancy outcomes.

Keyphrases

induced apoptosis
dna methylation
pregnancy outcomes
cell cycle arrest
pregnant women
cell migration
gene expression
oxidative stress
genome wide
endoplasmic reticulum stress
signaling pathway
cell death
cell proliferation
cerebrospinal fluid
drug induced