Association of mitochondrial DNA copy number with metabolic syndrome and type 2 diabetes in 14 176 individuals.

F FazziniC LaminaA RaftopoulouA KollerC FuchsbergerC PattaroF M Del GrecoP DöttelmayerL FendtJ FritzH MeiselbachS SchönherrL ForerH WeissensteinerP P PramstallerK-U EckardtA A HicksFlorian Kronenbergnull null

Published in: Journal of internal medicine (2021)

Our data show an inverse association of mtDNA-CN with higher risk of metabolic syndrome and type 2 diabetes. A major part of the total effect of mtDNA-CN on type 2 diabetes is mediated by obesity parameters.

Keyphrases

mitochondrial dna
copy number
type diabetes
metabolic syndrome
insulin resistance
glycemic control
genome wide
dna methylation
cardiovascular disease
lymph node metastasis
adipose tissue
high fat diet induced
squamous cell carcinoma
weight loss
physical activity
weight gain