Shear Stress Triggers Angiogenesis of Late Endothelial Progenitor Cells via the PTEN/Akt/GTPCH/BH4 Pathway.

Shao-Hong WuFeng ZhangShun YaoLu TangHai-Tao Zeng Ling-Ping Zhu Zhen Yang

Published in: Stem cells international (2020)

This study provides the first evidence that shear stress triggers angiogenesis in late EPCs via the PTEN/Akt/GTPCH/BH4 pathway, providing a potential nonpharmacologic therapeutic strategy for promoting angiogenesis in ischemia-related diseases.

Keyphrases

endothelial cells
cell proliferation
vascular endothelial growth factor
signaling pathway
pi k akt
wound healing
human health
risk assessment
climate change