Predictive metabolic networks reveal sex- and APOE genotype-specific metabolic signatures and drivers for precision medicine in Alzheimer's disease.

Rui ChangEugenia TrushinaKuixi ZhuSyed Shujaat Ali ZaidiBranden M LauAlexandra Kueider-PaisleySara MoeinQianying HeMelissa L AlampreseBarbora VagnerovaAndrew TangRamachandran VijayanYanyun LiuAndrew J SaykinRoberta D BrintonRima Kaddurah-Daouknull null

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)

These findings provide an initial but critical step in developing a diagnostic platform for personalized medicine by integrating metabolomic profiling and cognitive assessments to identify targeted precision therapeutics for AD patient subgroups through computational network modeling.

Keyphrases

cognitive decline
genome wide
single cell
case report
high throughput
small molecule
high fat diet
cancer therapy
dna methylation
mild cognitive impairment
adipose tissue