Metabolic engineering of the cellulolytic thermophilic fungus Myceliophthora thermophila to produce ethanol from cellobiose.

Jinyang LiYongli ZhangJingen LiTao SunChaoguang Tian

Published in: Biotechnology for biofuels (2020)

This is the first attempt to engineer the cellulolytic fungus M. thermophila to produce bioethanol from biomass-derived sugars such as glucose and cellobiose. The ethanol production can be improved about 4 times up to 11 grams per liter on cellobiose after a couple of genetic engineering. These results show that M. thermophila is a promising platform for bioethanol production from cellulosic materials in the future.

Keyphrases

anaerobic digestion
current status
genome wide
high throughput
blood glucose
copy number
gene expression
blood pressure
skeletal muscle
glycemic control