Comparative Cholinesterase, α-Glucosidase Inhibitory, Antioxidant, Molecular Docking, and Kinetic Studies on Potent Succinimide Derivatives.
Ashfaq AhmadFarhat UllahAbdul SadiqMuhammad AyazMuhammad Saeed JanMuhammad ShahidAbdul WadoodFawad MahmoodUmer RashidRiaz UllahMuhammad Umar Khayam SahibzadaAli S AlqahtaniHafiz Majid MahmoodPublished in: Drug design, development and therapy (2020)
Both succinimide derivatives exhibited considerable inhibitory activities against cholinesterases and α-glucosidase enzymes. Of these two, compound 1 revealed to be more potent against all the in-vitro targets which was supported by molecular docking with the lowest binding energies. Moreover, compound 1 also proved to have antiradical properties.