Silent hypoxaemia in COVID-19 patients.
Tatum S SimonsonTracy L BakerRobert B B BanzettTammie BishopJerome A DempseyJack L FeldmanPatrice G GuyenetEmma J HodsonGordon S MitchellEsteban A MoyaBrandon T NokesJeremy E OrrRobert L OwensMarc J PoulinJean M RawlingChristopher N SchmicklJyoti J WattersMagdy YounesAtul MalhotraPublished in: The Journal of physiology (2021)
The clinical presentation of COVID-19 due to infection with SARS-CoV-2 is highly variable with the majority of patients having mild symptoms while others develop severe respiratory failure. The reason for this variability is unclear but is in critical need of investigation. Some COVID-19 patients have been labelled with 'happy hypoxia', in which patient complaints of dyspnoea and observable signs of respiratory distress are reported to be absent. Based on ongoing debate, we highlight key respiratory and neurological components that could underlie variation in the presentation of silent hypoxaemia and define priorities for subsequent investigation.
Keyphrases
- sars cov
- respiratory failure
- end stage renal disease
- respiratory syndrome coronavirus
- case report
- chronic kidney disease
- newly diagnosed
- coronavirus disease
- extracorporeal membrane oxygenation
- peritoneal dialysis
- prognostic factors
- mechanical ventilation
- early onset
- acute respiratory distress syndrome
- intensive care unit
- physical activity
- drug induced
- subarachnoid hemorrhage