Stimuli-responsive assembly and disassembly of anionic suprasomes with tunable antibacterial activity.

Host-guest complexation-based suprasomes successfully deliver benzimidazolium amphiphiles. β-CD and Zn 2+ or an acidic environment act as the stimuli for the assembly and disassembly of suprasomes. The supramolecular nanomedicine developed by encapsulating tetracycline showed strong and tunable antibacterial activity and holds potential for the next-generation vesicle-based drug delivery system.