Transfer of Cardiac Mitochondria Improves the Therapeutic Efficacy of Mesenchymal Stem Cells in a Preclinical Model of Ischemic Heart Disease.

Marie Luce VignaisJennyfer LevouxPierre SicardKhattar KhattarCatherine LozzaMarianne GervaisSafia MezhoudJean NakhleFrederic RelaixOnnik AgbulutJeremy Fauconnier Anne-Marie Rodriguez

Published in: Cells (2023)

The preconditioning of MSCs with the artificial transfer of cardiac mitochondria appears to be promising strategy to improve the efficacy of MSC-based cell therapy in ischemic heart disease.

Keyphrases

cell therapy
mesenchymal stem cells
umbilical cord
left ventricular
stem cells
cell death
bone marrow
reactive oxygen species
endoplasmic reticulum
ischemia reperfusion injury
cerebral ischemia
heart failure
electron transfer
oxidative stress