Genetic biomarkers of methotrexate response and safety in Crohn's disease: Data from the Spanish ENEIDA registry.

Juliana SalazarEsther Garcia-PlanellaAgnès Fernández-ClotetMaria EsteveJavier P GisbertDavid BusquetsAlfredo LucendoLucía MárquezJordi GuardiolaMaría Dolores Martín-ArranzEva IglesiasDavid MonfortAlbert VilloriaFiorella CañeteOlga BellElena RicartYamile ZabanaMaría ChaparroEugeni DomènechJordi Gordillonull null

Published in: British journal of clinical pharmacology (2024)

Our study shows that variants of MTHFR and DHFR genes may be associated with MTX efficacy and adverse events in patients with CD.

Keyphrases

genome wide
copy number
high dose
electronic health record
big data
gene expression
transcription factor
genome wide identification