Blood-brain barrier integrity impacts the use of plasma amyloid-β as a proxy of brain amyloid-β pathology.
Bruna BellaverAlbert Puig-PijoanJoão Pedro Ferrari-SouzaDouglas T LeffaFiroza Z LussierPamela C L FerreiraCécile TissotGuilherme PovalaJoseph TherriaultAndréa L BenedetNicholas J AshtonStijn ServaesMira ChamounJenna StevensonNesrine RahmouniMarie VermeirenArthur C MacedoAida Fernández-LebreroGreta García-EscobarIrene Navalpotro-GómezOscar LopezDana L TudorascuAnn CohenVictor L VillemagneWilliam E KlunkSerge GauthierEduardo R ZimmerThomas K KarikariKaj BlennowHenrik ZetterbergMarc Suarez-CalvetPedro Rosa-NetoTharick A PascoalPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
BBB permeability affects the association between brain and plasma Aβ levels. BBB integrity does not affect the association between brain and plasma p-tau levels. Plasma Aβ was most affected by BBB permeability in AD-related brain regions. BBB permeability increases with age but not according to cognitive status.