A nitroxyl-responsive near-infrared fluorescent chemosensor for visualizing H2S/NO crosstalk in biological systems.

Mingwang YangJiangli Fan Wen Sun Jianjun DuSaran LongKun ShaoXiaojun Peng

Published in: Chemical communications (Cambridge, England) (2019)

We present a near-infrared (NIR) fluorescent probe, NR-HNO, which was successfully applied to visualizing H2S/NO "crosstalk" by the fluorescence detection of nitroxyl with a fast response time (5 min) and a large Stokes shift (131 nm) in living cells and tissue; it was also used to image nitroxyl in live mice.

Keyphrases

living cells
fluorescent probe
single molecule
deep learning
photodynamic therapy
high fat diet induced
cancer therapy
loop mediated isothermal amplification
type diabetes
label free
real time pcr
metabolic syndrome
adipose tissue
insulin resistance
fluorescence imaging
sensitive detection