A crossover study evaluating the sex-dependent and sensitizing effects of sleep deprivation using a nociceptive test battery in healthy subjects.

Hemme J HijmaIngrid KoopmansErica KlaassenRobert Jan DollRob G J A Zuiker Geert Jan Groeneveld

Published in: British journal of clinical pharmacology (2022)

TSD induced sex-dependent hyperalgesia on cold, heat and pressure pain, and CPM response. These results suggest that the TSD model may be suitable to evaluate (novel) analgesics in early-phase drug studies.

Keyphrases

neuropathic pain
chronic pain
drug induced
high glucose
pain management
spinal cord injury
physical activity
sleep quality
postoperative pain
case control
solid state