Preclinical studies on the toxicology, pharmacokinetics and safety of K1-70TM a human monoclonal autoantibody to the TSH receptor with TSH antagonist activity.
Jadwiga FurmaniakJane SandersJill ClarkJane WilmotPaul SandersYang LiBernard Rees Smith
Published in: Auto- immunity highlights (2019)
The toxicology, pharmacodynamic and pharmacokinetic data in this preclinical study were helpful in designing the first in human study with K1-70™ administered to subjects with Graves' disease.