Heparin Dosing Regimen Optimization in Veno-Arterial Extracorporeal Membrane Oxygenation: A Pharmacokinetic Analysis.

Julien Lanoiselée Jérémy MourerMarie JunglingSerge MolliexLise ThellierJulien TabareauEmmanuelle JeanpierreEmmanuel RobinSophie SusenBenoit TavernierAndré VincentelliEdouard OllierMouhamed Djahoum Moussa

Published in: Pharmaceutics (2024)

In adult patients on VA-ECMO, heparin's effect increased with serum creatinine and medical indication, whereas it decreased with body weight and systemic inflammation. We propose an optimized dosing regimen accounting for key covariates, capable of accurately predicting a given anti-Xa target.

Keyphrases

extracorporeal membrane oxygenation
body weight
acute respiratory distress syndrome
venous thromboembolism
respiratory failure
growth factor
healthcare
mechanical ventilation
uric acid
intensive care unit
data analysis