Association of Genetically Predicted Serum Estradiol With Risk of Thromboembolism in Men: A Mendelian Randomization Study.
Maria NethanderJohan QuesterLiesbeth VandenputClaes OhlssonPublished in: The Journal of clinical endocrinology and metabolism (2021)
Genetically predicted estradiol was inversely associated with the risk of thromboembolism and ischemic stroke in men. The ratio between testosterone and estradiol, determined by CYP19A1 activity, may contribute to the overall impact of sex steroids on thromboembolism in men.