The antidepressant effect of bone marrow mononuclear cell transplantation in chronic stress.
Pedro Antônio Schmidt do Prado-LimaGuilherme Ary OnstenGutierre Neves de OliveiraGuilherme Camargo BritoIsadora Machado GhilardiEduardo Vieira de SouzaPaula Gabrielli Dos SantosSimone Denise SalamoniDenise Cantarelli MachadoMarta Medeiros Frescura DuarteFernanda BarbisanIvana Beatrice Mânica da CruzZaquer Suzana Munhoz Costa-FerroJaderson Costa da CostaPublished in: Journal of psychopharmacology (Oxford, England) (2019)
These findings suggest administration of BMMC in rats subjected to CS restores sucrose preference, resolves inflammation in both the peripheral and central nervous system, as well as diminishes DNA damage. This effect was similar to that of escitalopram, which is effective in the treatment of depressive patients.
Keyphrases
- dna damage
- bone marrow
- oxidative stress
- major depressive disorder
- end stage renal disease
- ejection fraction
- newly diagnosed
- cell therapy
- bipolar disorder
- mesenchymal stem cells
- single cell
- stress induced
- peripheral blood
- peritoneal dialysis
- prognostic factors
- stem cells
- combination therapy
- patient reported
- cerebrospinal fluid
- drug induced
- chemotherapy induced