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C. elegans epicuticlins define specific compartments in the apical extracellular matrix and function in wound repair.

Murugesan PooranachithraErin M JyoAndreas M ErnstAndrew D Chisholm
Published in: bioRxiv : the preprint server for biology (2024)
epicuticlin (EPIC) proteins localize to specific regions in cortical and interfacial cuticle Epicuticlins colocalize with BLI collagens in struts in adult cuticleEPIC-3 is normally expressed in dauer stage and upregulated by skin woundingMutants lacking all three epicuticlins are viable and show reduced survival after skin wounding.
Keyphrases
  • extracellular matrix
  • wound healing
  • soft tissue
  • young adults
  • surgical site infection