NIR-Mediated Cu 2 O/Au Nanomotors for Synergistically Treating Hepatoma Carcinoma Cells.
Ting XianYilin LiuQingtao SongJing LiWenjuan LiuZhongwei GuPublished in: Chemistry, an Asian journal (2024)
We presented a NIR-driven Janus Cu 2 O/Au nanomotor. The nanomotor has a truncated octahedral structure. By asymmetric Au evaporation, the light response range of Cu 2 O nanomotor is extended to near-infrared range, and the speed of Cu 2 O/Au nanomotors under NIR is significantly increased. In promoting apoptosis of hepatocellular carcinoma, except the nanotoxicity of Cu 2 O itself, the Au layer enhances the photothermal properties, allowing Cu 2 O/Au nanomotors to induce apoptosis in hepatocellular carcinoma cells by heating them. On the other hand, a Schottky barrier formed at the interface of Cu 2 O and Au, preventing the recombination of electrons, which makes more electrons react with biomolecules to produce toxic ROS to kill hepatocellular cells. The killing rate of hepatocellular carcinoma cells reached 87 % by the combined effect of nanotoxicity inhibition of proliferation and photothermal & photodynamic therapy (PTT & PDT). Nanomotors in combination with multiple approaches are explored as a new treatment to tumor in this article.
Keyphrases
- photodynamic therapy
- sensitive detection
- reduced graphene oxide
- aqueous solution
- cell cycle arrest
- fluorescence imaging
- metal organic framework
- drug release
- cell death
- oxidative stress
- endoplasmic reticulum stress
- drug delivery
- induced apoptosis
- dna damage
- quantum dots
- fluorescent probe
- signaling pathway
- visible light
- cell proliferation
- dna repair
- reactive oxygen species
- combination therapy