Experimental study of the protective effect of mesosilica-supported 5-hydroxymethylfurfural on UV-induced aging of human dermal fibroblasts.
Xueming NiuZhenyu WangLong ZhangYunyun QuanKun WeiPublished in: RSC advances (2018)
The drug 5-HMF (5-hydroxymethylfurfural, C 6 H 6 O 3 ) is extensively studied for its antioxidative and anti-inflammatory properties. However, its unstable properties and biotoxicity restrict its use in skin care products and therapy. The present study was aimed at evaluating the potential of three-dimensional dendritic mesoporous silica nanospheres (3D-dendritic MSNs) as a topical carrier system for 5-HMF delivery. The encapsulation of the carrier also enhances the stability of the drug. Based on the results of Brunauer-Emmet-Teller (BET) analysis, Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), dynamic light scattering (DLS), and UV-vis diffuse reflectance spectroscopy, drug delivery systems were successfully fabricated and the loading capacity (LC%) and entrapment efficiency (EE%) were also assessed. In vitro cell tests revealed the outstanding biocompatibility and inoxidizability of 3D-dendritic MSNs. There is no effect on the antioxidant properties of the drug. Therefore, mesoporous silica can be combined with 5-HMF and used as potential antioxidant medicine in cosmetic applications.
Keyphrases
- anti inflammatory
- electron microscopy
- drug induced
- oxidative stress
- single cell
- endothelial cells
- wound healing
- cell therapy
- high resolution
- adverse drug
- emergency department
- mass spectrometry
- bone marrow
- multidrug resistant
- quality improvement
- simultaneous determination
- climate change
- health insurance
- smoking cessation
- electronic health record
- chemotherapy induced