The Clinicogenomic Landscape of Induction Failure in Childhood and Young Adult T-Cell Acute Lymphoblastic Leukemia.
David O'ConnorJonas DemeulemeesterLucia CondeAmy KirkwoodKent FungFoteini PapaleonidopoulouGianna BloyeNadine FarahSunniyat RahmanJeremy HancockCaroline M BatemanSarah InglottJon MeeJavier HerreroPeter Van LooAnthony V MoormanAjay VoraMarc R MansourPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
The outcome of IF in T-ALL remains poor with current therapy. The lack of a unifying genetic driver suggests alternative approaches, particularly using immunotherapy, are urgently needed.