Activation of Adaptive and Innate Immune Cells via Localized IL2 Cytokine Factories Eradicates Mesothelioma Tumors.

Amanda M Nash Samira Aghlara-Fotovat Bertha Castillio Andrea Hernandez Aarthi Pugazenthi Hyun-Sung Lee Hee-Jin Jang Annie Nguyen Alexander Lu Bryan M Burt Ravi K Ghanta Omid Veiseh

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

IL2 cytokine factories led to the eradication of aggressive mouse malignant mesothelioma tumors and protection from tumor recurrence, and increased the therapeutic efficacy of aPD1 checkpoint therapy. This study provides support for the clinical evaluation of this IL2-based delivery system. See related commentary by Palanki et al., p. 5010.

Keyphrases

innate immune
induced apoptosis
cell cycle
signaling pathway
mesenchymal stem cells
cell death
cell therapy
replacement therapy
light emitting